Endocrine Abstracts

Tissue and cell type specific control of glucocorticoid receptor (GR) levels is thought to occur through the usage of alternate promoters, and associated non-coding alternate first exons. The vast majority of the known alternative first exons are located within a 3.2 kbp CpG island. Methylation of certain CpG dinucleotides within the rat Gr promoter has been implicated in changes in hippocampal GR expression levels and the resultant disturbances in the HPA axis.<...

Myasthenia gravis (MG) and Graves’ ophthalmopathy (GO) share many clinical characteristics but may also co-exist. Both are autoimmune disorders mediated by organ specific pathogenic autoantibodies to membrane surface receptors. Differential diagnosis and/or co-existence provides a potential management challenge, and there is a paucity of demographic information regarding precise prevalence rates and concurrence of disease.Method: Re...

Background: Thyroid eye disease (TED) affects 25% of patients with Graves’ disease (GD). GD affects nearly 1% of pregnancies. However, data on TED incidence, course, management and outcome in pregnancy are limited.Aims: To describe the prevalence, course and outcomes of TED in pregnant females.Methods: A retrospective analysis of electronic health records was conducted in a sp...